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The human growth hormone or hGH was first observed in 1920, although its benefits have been discovered by the 1950. The benefits of this hormone thrilled the medical and scientific communities. However, doctors were still unable to use mass for disorders of growth because they were unable to secure a stable supply of the hormone.
Initially, scientists began to isolate the bovine growth hormone for use in HGH-deficient humans. However, as they quickly discovered the hormone bovine growth is structurally different from HGH. The treatments were so successful. Attempts to use of growth hormones from primates have been unsuccessful because the hormone was found to be inactive in humans.
Subsequently, the attempt was to isolate HGH from the pituitary gland of cadavers. This produces a few drops a corpse so that while a large number of corpses were necessary. The first successful treatment using this method was by Dr. Maurice Raben, an endocrinologist at Tufts University of Medicine in Boston, Massachusetts. He was able to purify enough cadaver-GH to treat a 17 year old boy with growth disorders. In 1970, cadaver-GH was marketed by a Swedish pharmaceutical company, Kabi.
Cadaver-GH was an ideal source of HGH still had it not to diagnose Creutzveldt-Jakob disease in four patients previously treated with cadaver-GH in 1985. More cases have been discovered in recent years and led to a wave of protests against the treatment. Cadaver-GH was quickly stopped by professionals and was quickly prohibited by governments worldwide.
In 1981, an American pharmaceutical company, Genentech, in collaboration with Kabi, produced the first synthesis HGH technology of recombinant DNA. This has been called rhGH and began to be used in therapy for hormone replacement the man soon after. Other laboratories such as Pfizer, Novo, Lilly and Merck quickly followed suit by marketing their own brands of HGH. Using technology of recombinant DNA, the problem of availability and disease transmission has been asked by cadaver-GH has been effectively treated.
The cost of rhGH remains very high. A standard treatment for growth failure can cost thousands of dollars per year. In severe cases, this cost can rise to over $ 35,000. This has prompted manufacturers to look for uses beyond the use of stunted children. Conditions such as pituitary tumors, chronic diseases and side effects of therapy for other medical conditions that have leads to a decrease in the natural production of HGH by the pituitary gland are treated.
HGH is now used in treating various conditions, including as an anti-aging drugs. It is also used to increase lean muscle mass and decrease body fat (fight against obesity for example). HGH is also used illegally by athletes to increase muscle mass and hence improve their strength. This illegal practice can could be prevented for long, because no test could distinguish between natural and synthetic HGH. However, since the Athens Olympics in 2004, new tests were introduced and the ban HGH could be executed.
Solution obviously a natural and completely sure must be found, studied and tested.
HGH Side Effects and Benefits
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